Microsoft has just announced that there is a problem with the SharePoint 2010 October Cummulative update.   If you’ve downloaded the October CU then DON’T install it, if you have already installed it, contact Microsoft Support for assistance.

Microsoft is working on guidance for what to do next.  The bug can cause the profile store to repeatedly crash.

See this blog for more information:

http://blogs.msdn.com/b/sharepoint/archive/2010/11/05/critical-information-about-the-sharepoint-server-2010-october-cumulative-update.aspx

Serge

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